Future of Engineering
Friday, April 18, 2008
Biocatalysts - Generics Pharmaceutical Manufacturers Go Green
Green chemistry incorporates concepts such as atom economy, convergency (higher process efficiency with fewer operations), reagent optimization (use of catalysis and more selective and recyclable reagents), and raw material efficiency.
One of the emerging green chemistry aspects is biocatalysts.
An advantage of these biocatalysts and of green chemistry in general, is the ability to manufacture a product in more generic facilities, compared to the demands of traditional chemocatalysis, which typically requires high pressure and high or low temperature reactors.
Another green chemistry strategy is telescoping, which aims to minimize the carryover of impurities from one process step to the next. The ability to make a product or an intermediate without any side products eliminates purification steps, saving time, energy, cost, and waste.
Interest in biocatalysis is high in the generics industry, in particular, as the generics manufacturers are actively seeking strategies to lower manufacturing costs and increase profit margins. It is predicted that biocatalysis technology will improve incrementally, with advances in proteomics enabling molecular evolution to be more directed and structure-based and less dependent on random mutagenesis.
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Keywords: Green chemistry, recyclable reagents, BioVerdant, IChemE Alex Tao, CSO, Codexis, biocatalytic enzymes, biocatalysts, green generic facilities, generics industry
Labels: Chemical-Engineering, Energy-Environment-Engineering
